| Please cite: I. S. Vlachos, N. Kostoulas, T. Vergoulis, G. Georgakilas, M. Reczko, M. Maragkakis, M. D. Paraskevopoulou, K. Prionidis, T. Dalamagas, A. G. Hatzigeorgiou DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways Nucleic Acids Research 2012 (Web server issue) | ||||||
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DIANA-miRPath is a miRNA pathway analysis web-server, providing accurate statistics, while being able to accommodate advanced pipelines. miRPath can utilize predicted miRNA targets (in CDS or 3’-UTR regions) provided by the DIANA-microT-CDS algorithm or even experimentally validated miRNA interactions derived from DIANA-TarBase v6.0. These interactions (predicted and/or validated) can be subsequently combined with sophisticated merging and meta-analysis algorithms.
miRPath v2.0 can perform advanced analysis pipelines, such as hierarchical clustering of miRNAs and pathways based on the levels of their interactions. Furthermore, users can easily create heat maps of miRNAs vs pathways interactions.
Other supported features include the identification of pathological single nucleotide polymorphisms (SNPs) in miRNA binding sites, as well as the “Reverse Search module”, where the user can identify all the predicted or experimentally validated miRNAs significantly targeting a selected pathway.